Inhibition of Ribonucleic Acid Polymerase by 5-Hydroxyuridine 5'-Triphosphate
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چکیده
منابع مشابه
Inhibition of Ribonucleic Acid Polymerase by 5-Hydroxyuridine 5’-Triphosphate*
5-Hydroxyuridine triphosphate was synthesized and its effectiveness as substrate for deoxyribonucleic acid-dependent ribonucleic acid polymerase was determined. The analogue was incorporated into RNA to a very low extent as compared to naturally occurring nucleoside triphosphates, and it replaced uridine triphosphate to a much greater extent than any of the other nucleoside triphosphates. The a...
متن کاملInhibition of ribonucleic acid polymerase by 5-hydroxyuridine 5'-triphosphate.
5-Hydroxyuridine triphosphate was synthesized and its effectiveness as substrate for deoxyribonucleic acid-dependent ribonucleic acid polymerase was determined. The analogue was incorporated into RNA to a very low extent as compared to naturally occurring nucleoside triphosphates, and it replaced uridine triphosphate to a much greater extent than any of the other nucleoside triphosphates. The a...
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Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosine 5'-triphosphate and guanosine 5'-triphosphate. RTP also inhibits ApG- and Gp...
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Sangivamycin is incorporated into RNA in the reaction catalyzed by the RNA polymerase from Micrococcus lysodeikticus with the use of calf thymus DNA or the copolymer of deoxyadenosine and deoxythymidine (poly d(A-T)). The incorporation of sangivamycin 5’4riphosphate into RNA is dependent on primer, time, protein concentration, and Mn++ or Mg+f. When calf thymus DNA is primer, GTP, CTP, and UTP ...
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Two major species of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) differing in size, pyridine nucleotide specificity, and susceptibility to inhibition by adenosine 5'-triphosphate (ATP) were detected in extracts of Pseudomonas multivorans (which has recently been shown to be synonymous with the species Pseudomonas cepacia) ATCC 17616. The large species (molecular weight ca. 230,000) was acti...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1966
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)96833-x